Group structure and culture: Our research activities fall under three main umbrellas: data, methods and software.

Please read more about our publication policy here. These efforts include the development of LD Score regression, an approach to delineate between confounding bias and polygenic inheritance in genome-wide association data, and C-alpha - a novel test for rare variants that is robust to variants conferring both risk and protective effects.Ĭommitment to sharing among the scientific community: We firmly believe in sharing consented genetic data and study results broadly, and believe there is tremendous value in enabling the wider scientific community the opportunity to independently investigate and data. We are also strong advocates of open access publication and commit to posting all of our manuscripts to an open access preprint server such as.

We're also conducting similar work to discover the first genetic risk loci for ADHD. Much of our research focuses on the development of new statistical approaches to understand the impact of genetic variation on human disease and variation. Group research: As part of the PGC team, we conducted the largest genome-wide association study (GWAS) of schizophrenia to date, uncovering 108 genetic loci robustly associated with schizophrenia risk.

These efforts underscore our commitment to understanding the genetic influences on psychiatric illness and how to translate those findings to insights into the biological basis of these diseases. We have developed novel statistical approaches and implemented these methods in open source software that has been widely adopted by the scientific community.

Expertise: Benjamin Neale has over a decade of experience in advancing statistical methodology for genetic studies, with an extensive track record of conducting analyses for big data, such as genome-wide association and next generation sequencing data. The majority of the group's research activities have been conducted as part of large-scale international consortia, with a particular focus on psychiatric illness including collaborative efforts on ADHD, Autism, and Schizophrenia as part of the Psychiatric Genomics Consortium (PGC).

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